Spinal Epidural Lipomatosis: A Rare Complication From Hormonal Therapy for Infantile Spasms.

Background: Spinal epidural lipomatosis (SEL) represents pathologic overgrowth of extradural adipose tissue in the spinal canal that can result in spinal cord compression. SEL has been associated with excess corticosteroids, whether from exogenous steroid use or from excess endogenous steroids. Spinal epidural lipomatosis is rarely reported in children and has not been reported in association with hormonal therapy for infantile spasms.

Methods: We performed a detailed retrospective chart and literature review.

Results: We describe two children with symptomatic SEL associated with the use of high-dose hormone treatment for infantile spasms.