CD56- CD16+ NK cells from HIV-infected individuals negatively regulate IFN-γ production by autologous CD8+ T cells.
Journal: Journal Of Leukocyte Biology
Published:
Abstract
The percentage of human CD56- CD16+ NK cells increases during chronic infection with human HIV; however, the biologic role of CD56- CD16+ NK cells in HIV infection is unclear. Our results demonstrate that the percentage of CD56- CD16+ NK cells producing IL-10 and TGF-β was higher than CD56dim CD16+ NK cells. CD56- CD16+ NK cells could inhibit IFN-γ production by autologous CD8+ T cells, and this inhibition could be partially reversed by anti-IL-10, anti-TGF-β, or anti-PD-L1 mAbs. CD56- CD16+ NK cells are potential targets for the development of novel immune therapies against HIV infection.
Authors
Meichen Ma, Xiaowan Yin, Xue Zhao, Chenxi Guo, Xiaoyu Zhu, Tingting Liu, Mei Yang, Zining Zhang, Yajing Fu, Jing Liu, Junjie Xu, Haibo Ding, Xiaoxu Han, Zhenxing Chu, Hong Shang, Yongjun Jiang