Tales from the Cryptkeeper: New Roles for Lats1/2 in Wnt-driven Homeostasis.
Journal: Cell Stem Cell
Published:
Abstract
In this issue of Cell Stem Cell, Li et al. (2020) reveal pivotal roles for Lats1/2 in adult, Wnt-mediated intestinal homeostasis through TEAD-dependent and -independent transcription. Loss of Lats1/2 mobilizes a previously unrecognized YAP/TAZ-Groucho/TLE interaction to suppress Wnt/TCF-mediated transcription, thereby resulting in intestinal stem cell depletion and Wnt-uncoupled progenitor expansion.
Authors
Vivian Fu, Kun-liang Guan