The association of miR-27a rs895819 polymorphism with colorectal cancer risk in Chinese population.

Background: Besides environment and living habits, such as a sedentary lifestyle, smoking and drinking, genetic variation also plays an important role in the development of colorectal cancer (CRC). This study was aimed to investigate the role of miR-27a rs895819 polymorphism on CRC risk in Chinese population.

Methods: In a case-control study including 208 CRC and 312 age- and gender-matched healthy control subjects, the rs895819 polymorphism was genotyped using the TaqMan allelic discrimination assay. Furthermore, a pooled analysis based on eligible studies was performed by using the STATA software.

Results: Logistic regression analysis showed that the rs895819 polymorphism was not associated with CRC risk. However, a pooled analysis based on five studies from Chinese population showed a statistically significant association between the rs895819 polymorphism and CRC risk (GG vs AA: OR = 1.56, 95% CI = 1.27-1.92, Pz < .01; (AG + GG) vs AA: OR = 1.14, 95% CI = 1.01-1.30, Pz = .04; GG vs (AG + AA): OR = 1.54, 95% CI = 1.27-1.88, Pz < .01; G vs A: OR = 1.20, 95% CI = 1.09-1.33, Pz < .01).

Conclusions: Our study suggests that miR-27a rs895819 polymorphism plays an important role in CRC risk in Chinese population and may serve as a valuable biomarker for predicting an individual's susceptibility to CRC.