Retinal Vein Occlusion and the Risk of Dementia: A Nationwide Cohort Study.

Purpose: Retinal vascular change is associated with changes in the brains of patients with dementia; however, there is limited evidence regarding the relationship between retinal vein occlusion (RVO) and risk of dementia. This study investigated the association between RVO and subsequent risk of dementia using a cohort consisting of the entire Korean population.

Design: Retrospective cohort study.

Methods: This study was based on the data from participants ≥40 years of age who underwent health examinations between 2009 and 2010 provided by the South Korean National Health Insurance Service. The RVO group (n = 46,259) consisted of patients whose initial diagnoses were between 2006 and 2010. The comparison group (3 per RVO patient; n = 138,777) was selected using propensity score matching according to age, sex, and systolic blood pressure. Multivariate Cox proportional hazard regression models were performed.

Results: During a mean follow-up of 6.6 years, 14,727 cases of dementia developed. From the Kaplan-Meier curves, probabilities of cases for all types of dementia were significantly increased in the RVO group, relative to the comparison group (all log-rank P <.001). After all confounding variables were adjusted, the RVO group exhibited increased risks of subsequent all-cause dementia (hazard ratio [HR]: 1.16; 95% confidence interval [CI]: 1.12-1.21), Alzheimer's disease (HR: 1.15; 95% CI: 1.11-1.20), and vascular dementia (HR: 1.24; 95% CI: 1.12-1.37), relative to the comparison group. The presence of RVO was significantly associated with increased risks of all 3 types of dementia both in hypertensive and nonhypertensive individuals.

Conclusions: In this large-scale population-based cohort study, RVO was significantly associated with increased risks of all-cause dementia, Alzheimer's disease, and vascular dementia.