Internal Alkyne-Directed Fluorination of Unactivated C(sp3)-H Bonds.
Journal: Organic Letters
Published:
Abstract
A silver-mediated internal alkyne-guided fluorination of unactivated C(sp3)-H bonds is described. The reaction provides a facile access to γ-fluorinated fluoroalkylated (Z)-alkenes from readily available alkynes in promising yields with excellent regioselectivity, stereoselectivity, and site selectivity.
Authors
Chenyun Shu, Jian Feng, Hanliang Zheng, Cungui Cheng, Zheliang Yuan, Zuxiao Zhang, Xiao-song Xue, Gangguo Zhu