Exploratory Study of the Effectiveness of Granulocyte and Monocyte Adsorptive Apheresis Before Initiation of Steroids in Patients With Active Ulcerative Colitis (EXPECT Study): A Multicenter Prospective Clinical Trial.
Journal: Crohn's & Colitis 360
Published:
Abstract
Background: Granulocyte and monocyte adsorptive apheresis (GMA) has been used for therapy of steroid-dependent/refractory ulcerative colitis (UC). The aim of this study was to investigate the effectiveness of GMA in UC patients not receiving steroids.
Methods: We conducted a single-arm, open-label, and multicenter prospective clinical trial. UC patients who had insufficient responses to 5-aminosalicylic acid received GMA twice a week for 5 weeks.
Results: The response rate of all patients was 58.2% (39/67). Of the 39 patients who achieved a response, 74.4% achieved endoscopically confirmed mucosal healing.
Conclusions: GMA shows effectiveness in inducing remission in UC patients not receiving steroid.
Authors
Kazuki Kakimoto, Minoru Matsuura, Takumi Fukuchi, Hitoshi Hongo, Tsuguhiro Kimura, Nobuo Aoyama, Yorihide Okuda, Kazuki Aomatsu, Noriko Kamata, Yoko Yokoyama, Chiemi Mizuno, Takuya Inoue, Takako Miyazaki, Shiro Nakamura, Kazuhide Higuchi, Hiroshi Nakase
Relevant Conditions