The correlation of serum Vaspin, S100A12 and PCT levels with the severity of ulcerative colitis and its clinical significance.

Objective: This study aimed to investigate the correlation between Vaspin, S100A12 and PCT levels and ulcerative colitis (UC).

Methods: This study included 104 patients with UC from November 2018 to June 2020 as the experimental group, including 37 cases in remission and 67 cases in an active phase; patients in an active phase were classified into 17 cases of mild, 37 cases of moderate and 13 cases of severe according to Modified Mayo Endoscopic Score (MMES). There were 104 patients as healthy controls during the same period who were enrolled as the control group. Serum levels of Vaspin, S100A12, PCT, inflammatory factors and immunoglobulins were compared between two groups and the correlation between serum levels of each index and the severity of UC was analyzed.

Results: Compared with the control group, serum Vaspin, S100A12, and PCT levels were higher in the experimental group, and serum Vaspin, S100A12, and PCT levels were higher in the active phase than in the remission phase (P < 0.05). Serum Vaspin, S100A12, PCT, IL-6, IL-17, TNF-α levels: Severe patients > moderate patients > mild patients; Serum IgA, IgG levels: Severe < moderate < mild (P < 0.05). As shown by Spearman analysis, serum Vaspin, S100A12, PCT, IL-6, IL-17, and TNF-α levels were positively correlated with (r=0.317, P=0.021) while serum IgA and IgM were negatively correlated with the severity of UC disease (r=-0.418, P=0.007).

Conclusions: Serum Vaspin, S100A12, PCT and inflammatory factor levels were positively correlated with the severity of UC disease, and they showed significance in the assessment of the severity and prognosis of UC.