Proton pump inhibitors therapy and the risk of hip fracture in older people in Taiwan.

Background: Conflicting results exist on the relationship between proton pump inhibitors use and hip fracture in old people. The objective of the paper was to explore this issue in Taiwan.

Methods: We conducted a population-based case-control study using the database of the Taiwan National Health Insurance Program. Cases included subjects aged 65 years and over with newly diagnosed hip fracture between 2000 and 2013 (n = 7208). Controls included subjects aged 65 years and over without a diagnosis of hip fracture (n = 7208). The cases and the controls were matched with sex, age, comorbidities, and index year of diagnosing hip fracture. The odds ratio and 95% confidence interval for hip fracture associated with proton pump inhibitors use were estimated by the multivariable logistic regression model.

Results: The adjusted odds ratio of hip fracture was 0.96 for subjects with current use of proton pump inhibitors (95% confidence interval 0.76, 1.22), 1.17 for subjects with recent use (95% confidence interval 0.90, 1.52), and 1.12 for subjects with late use (95% confidence interval 0.91, 1.38), compared with never use.

Conclusions: No significant association can be detected between proton pump inhibitors use and the risk of hip fracture in older people in Taiwan.