5-Aminolevulinic acid photodynamic therapy combined with CO2 laser therapy for the treatment of cutaneous Rosai-Dorfman disease: A case report.

We report the case of a patient diagnosed with cutaneous Rosai-Dorfman disease (CRDD) who was treated successfully with 5-aminolevulinic acid photodynamic therapy (ALA-PDT) combined with carbon dioxide (CO2) laser therapy. CRDD is a rare form of Rosai-Dorfman disease that has various clinical presentations and multiple possible therapies with varying efficacies. ALA-PDT combined with CO2 laser therapy was safe and effective for treating CRDD in the current patient, with no recurrence during the 3 months of follow-up medical examinations. This case suggests that ALA-PDT combined with CO2 laser can be used to treat patients with CRDD.