Comparative animal experiment studies of the effect of exogenous collagen on healing of a deep skin wound

The high number of available wound dressings as well as the scientific reports about this topic indicates that the problem of an ideal wound dressing material is not jet solved. In the last 30 years lot of scientific reports about collagen as wound covering has been published. The positive effect of collagen by this application on a wound is well-known. We investigated the effect of a collagen sponge on healing of full thickness wound in rats. The animals were divided in two control and two experimental groups. In the control groups there were air exposed wounds as well as wounds covered with paraffin gauze. In the experimental groups the wounds were covered with natural reconstituted collagen sponge as well as with chemically prepared sponge. All results were compared. The wounds with collagen sponge covering healed significantly faster. Also the quality of the wound healing was better in the experimental groups.