Urodynamic effect of vibegron on neurogenic lower urinary tract dysfunction in individuals with spinal cord injury: A retrospective study.

Study

Design: A Retrospective study.

Objectives: To investigate the effects of vibegron on urodynamic parameters of individuals with spinal cord injury (SCI). Setting: The National Hospital Organization, Murayama Medical Center, Japan.

Methods: We retrospectively analyzed the urodynamic parameters of 31 individuals with SCI within one year after injury, who were diagnosed with neurogenic lower urinary tract dysfunction (NLUTD) according to a urodynamic study (UDS), and prescribed vibegron between December 2018 and December 2020. Treatment criteria were as follows: cystometric capacity of <200 mL, bladder compliance of <20 mL/cmH2O, and/or presence of detrusor overactivity in the first UDS. We compared urodynamic data before and after vibegron treatment.

Results: Vibegron administration increased the maximum cystometric capacity (MCC) (median, from 185.0 to 340.0 mL, P = 0.001), bladder compliance (median, from 8.3 to 20.0 mL/cmH2O, P < 0.001).

Conclusion: Vibegron therapy improved the bladder capacity and bladder compliance of individuals with NLUTD and SCI.