Enantioselective [3 + 2] Cycloaddition of Vinylcyclopropanes with Alkenyl N-Heteroarenes Enabled by Palladium Catalysis.
Journal: Organic Letters
Published:
Abstract
The first catalytic enantioselective [3 + 2] cycloaddition reaction between vinylcyclopropanes and alkenyl N-heteroarenes in the presence of LiBr and a Pd(0)/SEGPHOS complex was developed. LiBr plays a key role in improving the reactivity of alkenyl N-heteroarenes as a mild Lewis acid.
Authors
Wen-dao Chu, Ya-ting Wang, Tian-tian Liang, Teng Long, Jia-yu Zuo, Zhihui Shao, Bo Chen, Cheng-yu He, Quan-zhong Liu