NCCN Guidelines® Insights: Gastrointestinal Stromal Tumors, Version 2.2022.
Journal: Journal Of The National Comprehensive Cancer Network : JNCCN
Published:
Abstract
Gastrointestinal stromal tumors (GIST) are the most common type of soft tissue sarcoma that occur throughout the gastrointestinal tract. Most of these tumors are caused by oncogenic activating mutations in the KIT or PDGFRA genes. The NCCN Guidelines for GIST provide recommendations for the diagnosis, evaluation, treatment, and follow-up of patients with these tumors. These NCCN Guidelines Insights summarize the panel discussion behind recent important updates to the guidelines, including revised systemic therapy options for unresectable, progressive, or metastatic GIST based on mutational status, and updated recommendations for the management of GIST that develop resistance to specific tyrosine kinase inhibitors.
Authors
Margaret Von Mehren, John Kane, Richard Riedel, Jason Sicklick, Seth Pollack, Mark Agulnik, Marilyn Bui, Janai Carr Ascher, Edwin Choy, Mary Connelly, Sarah Dry, Kristen Ganjoo, Ricardo Gonzalez, Ashley Holder, Jade Homsi, Vicki Keedy, Ciara Kelly, Edward Kim, David Liebner, Martin Mccarter, Sean Mcgarry, Nathan Mesko, Christian Meyer, Alberto Pappo, Amanda Parkes, Ivy Petersen, Matthew Poppe, Scott Schuetze, Jacob Shabason, Matthew Spraker, Melissa Zimel, Mary Bergman, Hema Sundar, Lisa Hang
Relevant Conditions