Inhibition of estradiol-induced intranuclear inclusions by an anti-estrogen (nafoxidine) in mammotrophs of the Mongolian gerbil.

Nafoxidine, an anti-estrogen, inhibited the induction of intranuclear inclusions by estradiol in mammotrophs of the male Mongolian gerbil. No inclusions were observed with inhibitor alone or in control-injected gerbils. Estrogen may well act directly on mammotrophs in induction of nuclear inclusions.