Highly Regioselective Synthesis of N-β-trifluoromethyl 2-pyridones via anti-Markovnikov Hydroamination of α-(trifluoromethyl)styrenes with 2-pyridones.

A novel and facile method for the synthesis of N-β-CF3 -substituted 2-pyridones via hydroamination of α-(trifluoromethyl)styrenes with 2-pyridones was described. The reaction proceeded smoothly at room temperature, affording a variety of N-(β-trifluoromethyl-β-arylethyl)pyridin-2(1H)-ones in moderate to good yields with excellent N-regioselectivity.