Oxidative cascade cyclization of N-arylacrylamides with TMSN3.
Journal: Organic & Biomolecular Chemistry
Published:
Abstract
An azido-radical-triggered cyclization of N-(o-cyanobiaryl)acrylamides with TMSN3via a C(sp3)-N/C(sp2)-C(sp3)/C(sp2)-N bond formation cascade is described. This reaction features mild conditions and high bond-forming efficiency, making it an efficient method for the construction of azide-substituted pyridophenanthridines.
Authors
Bo Jiang, Tai-gang Fan, Yu-song Ran, Yun-tao Shen, Cui Zhang, Wei Jiang, Ya-min Li