Characteristics of myelodysplastic syndromes with der(1;7)(q10;p10)
Journal: [Rinsho Ketsueki] The Japanese Journal Of Clinical Hematology
Published:
Abstract
der(1;7)(q10;p10) is a derivative chromosome generated by an unbalanced translocation between chromosomes 1 and 7 during DNA replication. It was first described in 1980, over 40 years ago, in a case report of three patients with myelofibrosis and myeloid metaplasia. This unbalanced translocation has been identified as a characteristic entity within myeloid neoplasms. Recent clinical and genetic studies comparing der(1;7)(q10;p10)(+) against -7/del(7q) have revealed that patients with der(1;7)(q10;p10)(+) MDS have a better prognosis and a unique mutational profile. This review discusses the clinical and genetic features of der(1;7)(q10;p10)(+) myeloid neoplasms.
Authors
Rurika Okuda
Relevant Conditions