To Analyze the Efficacy of Platelet-rich Plasma in Contrast to Platelet-rich Fibrin along with Synthetic Nanocrystalline Hydroxyapatite and β-tricalcium Phosphate Bone Graft in Regeneration of Bony Defects in Children.

To analyze the efficacy of platelet-rich plasma (PRP) in contrast to platelet-rich fibrin (PRF) along with synthetic nanocrystalline hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP) bone graft in the regeneration of bone defects in children. A total of 20 children in whom bone defect was present were selected and divided into two groups of 10. In group I, the bone defect was filled with PRP + nanocrystalline HA with β-TCP and group II, with PRF + nanocrystalline HA with β-TCP. Radiographs using VistaScan with a mesh grid were taken to analyze the bone density and bone regeneration. Clinical evaluation with respect to the color of overlying mucosa, sinus formation, pus discharge, and seepage of bone graft was done. The parameters used to analyze the radiographs included gray scale analysis, residual bone defect calculation in pixels both performed in CorelDraw version 13 software, and radiopaque scoring scale. The mean bone defect density measured using gray scale was higher in the PRF than PRP group. The percentage of bone formation analyzed using residual bone defect calculation and mean radiopaque score revealed that the PRF group showed better outcomes compared to the PRP group. Both PRP and PRF are equally effective in promoting bone regeneration with PRF showing slight superiority over PRP. Koksi Sangma Shadap NM, Yadav G, Saha S, et al. To Analyze the Efficacy of Platelet-rich Plasma in Contrast to Platelet-rich Fibrin along with Synthetic Nanocrystalline Hydroxyapatite and β-tricalcium Phosphate Bone Graft in Regeneration of Bony Defects in Children. Int J Clin Pediatr Dent 2023;16(6):842-849.