Zn(II)-catalyzed asymmetric [3 + 2] cycloaddition of acyclic enones with azomethine ylides.

The Zn(II)/UCD-Imphanol-catalyzed highly endo-selective [3 + 2] asymmetric cycloaddition of acyclic enones and azomethine ylides has been developed. Moderate to high yields (up to 94%) with excellent endo/exo selectivities (99 : 1) and enantioselectivities up to 96.5 : 3.5 er were obtained.