Dynamic proportional loss of functional connectivity revealed change of left superior frontal gyrus in subjective cognitive decline: an explanatory study based on Chinese and Western cohorts.
Journal: GeroScience
Published:
Abstract
Brain network dynamics have been extensively explored in patients with subjective cognitive decline (SCD). However, these studies are susceptible to individual differences, scanning parameters, and other confounding factors. Therefore, how to reveal subtle SCD-related subtle changes remains unclear. Cross-sectional and longitudinal resting-state functional magnetic resonance imaging data from both Chinese and Western populations were analyzed. We proposed a framework of dynamic proportional loss of functional connectivity (DPLFC). After its stability was validated, the optimal parameters were applied for the clinical diagnosis of SCD. DPLFC yielded a relatively high intraclass correlation coefficient. In particular, the DPLFC of the left superior frontal gyrus (SFG) progressively decreased along the Alzheimer's disease (AD) continuum. Compared with the traditional index, the DPLFC had better classification performance between cognitively normal controls and patients with SCD. Furthermore, DPLFC was related to Aβ deposition and scale scores. Patients with lower DPLFC values had a greater risk of cognitive decline. Decreased DPLFC in the left SFG may be a potential AD-related neuroimaging biomarker at an early stage.
Authors
Luyao Wang, Wenjing Hu, Fan Dong, Can Sheng, Jinglong Wu, Ying Han, Jiehui Jiang, Paul Aisen, Ronald Petersen, Clifford Jack, William Jagust, John Trojanowski, Arthur Toga, Laurel Beckett, Robert Green, Andrew Saykin, John Morris, Leslie Shaw, Zaven Khachaturian, Greg Sorensen, Lew Kuller, Marcus Raichle, Steven Paul, Peter Davies, Howard Fillit, Franz Hefti, David Holtzman, Marek Mesulam, William Potter, Peter Snyder, Adam Schwartz, Tom Montine, Ronald Thomas, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Danielle Harvey, Matthew Bernstein, Paul Thompson, Norbert Schuff, Bret Borowski, Jeff Gunter, Matt Senjem, Prashanthi Vemuri, David Jones, Kejal Kantarci, Chad Ward, Robert Koeppe, Norm Foster, Eric Reiman, Kewei Chen, Chet Mathis, Susan Landau, Nigel Cairns, Erin Householder, Lisa Taylor Reinwald, Virginia Lee, Magdalena Korecka, Michal Figurski, Karen Crawford, Scott Neu, Tatiana Foroud, Steven Potkin, Li Shen, Kelley Faber, Sungeun Kim, Kwangsik Nho, Leon Thal, Neil Buckholtz, Marylyn Albert, Richard Frank, John Hsiao, Jeffrey Kaye, Joseph Quinn, Betty Lind, Raina Carter, Sara Dolen, Lon Schneider, Sonia Pawluczyk, Mauricio Beccera, Liberty Teodoro, Bryan Spann, James Brewer, Helen Vanderswag, Adam Fleisher, Judith Heidebrink, Joanne Lord, Sara Mason, Colleen Albers, David Knopman, Kris Johnson, Rachelle Doody, Javier Villanueva Meyer, Munir Chowdhury, Susan Rountree, Mimi Dang, Yaakov Stern, Lawrence Honig, Karen Bell, Beau Ances, Maria Carroll, Sue Leon, Mark Mintun, Stacy Schneider, Angela Oliver, Daniel Marson, Randall Griffith, David Clark, David Geldmacher, John Brockington, Erik Roberson, Hillel Grossman, Effie Mitsis, Leyla De Toledo Morrell, Raj Shah, Ranjan Duara, Daniel Varon, Maria Greig, Peggy Roberts, Chiadi Onyike, Daniel D'agostino, Stephanie Kielb, James Galvin, Brittany Cerbone, Christina Michel, Henry Rusinek, Mony De Leon, Lidia Glodzik, Susan De Santi, Pmurali Doraiswamy, Jeffrey Petrella, Terence Wong, Steven Arnold, Jason Karlawish, David Wolk, Charles Smith, Greg Jicha, Peter Hardy, Partha Sinha, Elizabeth Oates, Gary Conrad, Oscar Lopez, Maryann Oakley, Donna Simpson, Anton Porsteinsson, Bonnie Goldstein, Kim Martin, Kelly Makino, Msaleem Ismail, Connie Brand, Ruth Mulnard, Gaby Thai, Catherine Mcadams Ortiz, Kyle Womack, Dana Mathews, Mary Quiceno, Ramon Diaz Arrastia, Richard King, Myron Weiner, Kristen Martin Cook, Michael Devous, Allan Levey, James Lah, Janet Cellar, Jeffrey Burns, Heather Anderson, Russell Swerdlow, Liana Apostolova, Kathleen Tingus, Ellen Woo, Daniel H Silverman, Po Lu, George Bartzokis, Neill Graff Radford, Francine Parfitt, Tracy Kendall, Heather Johnson, Martin Farlow, Ann Hake, Brandy Matthews, Scott Herring, Cynthia Hunt, Christopher Van Dyck, Richard Carson, Martha Macavoy, Howard Chertkow, Howard Bergman, Chris Hosein, Ging-yuek Hsiung, Howard Feldman, Benita Mudge, Michele Assaly, Charles Bernick, Donna Munic, Andrew Kertesz, John Rogers, Dick Trost, Diana Kerwin, Kristine Lipowski, Chuang-kuo Wu, Nancy Johnson, Carl Sadowsky, Walter Martinez, Teresa Villena, Raymond Turner, Kathleen Johnson, Brigid Reynolds, Reisa Sperling, Keith Johnson, Gad Marshall, Meghan Frey, Barton Lane, Allyson Rosen, Jared Tinklenberg, Marwan Sabbagh, Christine Belden, Sandra Jacobson, Sherye Sirrel, Neil Kowall, Ronald Killiany, Andrew Budson, Alexander Norbash, Patricia Johnson, Joanne Allard, Alan Lerner, Paula Ogrocki, Leon Hudson, Evan Fletcher, Owen Carmichae, John Olichney, Charles Decarli, Smita Kittur, Michael Borrie, T-y Lee, Rob Bartha, Sterling Johnson, Sanjay Asthana, Cynthia Carlsson, Adrian Preda, Dana Nguyen, Pierre Tariot, Stephanie Reeder, Vernice Bates, Horacio Capote, Michelle Rainka, Douglas Scharre, Maria Kataki, Anahita Adeli, Earl Zimmerman, Dzintra Celmins, Alice Brown, Godfrey Pearlson, Karen Blank, Karen Anderson, Robert Santulli, Tamar Kitzmiller, Eben Schwartz, Kaycee Sink, Jeff Williamson, Pradeep Garg, Franklin Watkins, Brian Ott, Henry Querfurth, Geoffrey Tremont, Stephen Salloway, Paul Malloy, Stephen Correia, Howard Rosen, Bruce Miller, Jacobo Mintzer, Kenneth Spicer, David Bachman, Stephen Pasternak, Irina Rachinsky, Dick Drost, Nunzio Pomara, Raymundo Hernando, Antero Sarrael, Susan Schultz, Laura L Ponto, Hyungsub Shim, Karen Smith, Norman Relkin, Gloria Chaing, Lisa Raudin, Amanda Smith, Kristin Fargher, Balebail Raj, Thomas Neylan, Jordan Grafman, Melissa Davis, Rosemary Morrison, Jacqueline Hayes, Shannon Finley, Karl Friedl, Debra Fleischman, Konstantinos Arfanakis, Olga James, Dino Massoglia, Jjay Fruehling, Sandra Harding, Elaine Peskind, Eric Petrie, Gail Li, Jerome Yesavage, Joy Taylor, Ansgar Furst
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