Eye Tracking as Biomarker Compared to Neuropsychological Tests in Parkinson Syndromes: An Exploratory Pilot Study Before and After Deep Transcranial Magnetic Stimulation.

Background/

Objectives: Neurodegenerative diseases such as Parkinson's disease (PD) are becoming increasingly prevalent, necessitating diverse treatment options to manage symptoms. The effectiveness of these treatments depends on accurate and sensitive diagnostic methods. This exploratory pilot study explores the use of eye tracking and compares it to neuropsychological tests on patients treated with deep transcranial magnetic stimulation (dTMS).

Methods: We used the HTC Vive Pro Eye VR headset with Tobii eye tracker to measure eye movements in 10 Parkinson syndrome patients while viewing three 360-degree scenes. Eye movements were recorded pre- and post-dTMS, focusing on Fixation Duration, Longest Fixation Period, Saccade Rate, and Total Fixations. Neuropsychological assessments (MoCA, TUG, BDI) were conducted before and after stimulation. dTMS was performed using the Brainsway device with the H5 helmet, targeting the motor cortex (1 Hz) and the prefrontal cortex (10 Hz) for 7-12 sessions.

Results: ROC analysis indicated a moderate ability to differentiate between states using eye movement parameters. Significant correlations were found between changes in the longest fixation period and MoCA scores (r = 0.65, p = 0.025), and between fixation durations and BDI scores (r = -0.55, p = 0.043). Paired t-tests showed no significant differences in eye movement parameters, but BDI scores significantly reduced post-dTMS (t(5) = 2.57, p = 0.049).

Conclusions: Eye-tracking parameters, particularly the Longest Fixation Duration and Saccade Rate, could serve as sensitive and feasible biomarkers for cognitive changes in Parkinson's Syndrome, offering a quick alternative to traditional methods. Traditional neuropsychological tests showed a significant improvement in depressive symptoms after dTMS. Further research with larger sample sizes is necessary to validate these findings and explore the diagnostic utility of eye tracking.