Efficacy and safety of thulium fiber laser versus holmium: yttrium-aluminum-garnet laser in lithotripsy for urolithiasis: a systematic review and meta-analysis.

This meta-analysis compares the efficacy and safety of thulium fiber laser (TFL) with holmium: yttrium-aluminum-garnet (Ho: YAG) laser in lithotripsy for urolithiasis. A literature search was conducted across PubMed, Embase, Web of Science, the Cochrane Central Register of Controlled Trials (CENTRAL), and ClinicalTrials.gov to identify studies published up to July 2024. Studies evaluating clinical outcomes for urolithiasis treated with either Ho: YAG laser or TFL were included. The meta-analysis, using RevMan 5.4 software, focused on comparing the stone-free rate (SFR) between the two lasers. A total of 21 studies were included. TFL was associated with a significantly higher SFR (RR 1.09, 95% CI: 1.02 to 1.16; P = 0.01), shorter operation time (SMD - 1.24, 95% CI: -1.82 to -0.66; P < 0.001), shorter lasing time (SMD - 1.26, 95% CI: -1.98 to -0.54; P < 0.001), shorter hospital stay (SMD - 2.08, 95% CI: -4.15 to -0.02; P = 0.05), reduced stone basket usage (SMD 0.50, 95% CI: 0.33 to 0.76; P = 0.001), and a lower total number of intraoperative complications (RR 0.67, 95% CI: 0.47 to 0.96; P = 0.03). However, TFL was also associated with a higher risk of postoperative sepsis (RR 5.32, 95% CI: 1.71 to 16.56; P = 0.004). Subgroup analyses revealed that TFL achieved a higher SFR in several subgroups, including ureteral stones, non-MOSES technology, and follow-up periods of ≥ 3 months, among others. In conclusion, TFL lithotripsy shows superior efficiency and safety compared to the Ho: YAG laser, though the increased risk of postoperative sepsis warrants further investigation.