Omeprazole with Calcium Hydroxide's Effectiveness as an Intracanal Medication against Enterococcus faecalis.

To evaluate the effectiveness of omeprazole mixed with calcium hydroxide (Ca(OH)2), as intracanal medicament in eliminating Enterococcus faecalis. Our study included 93 extracted mandibular premolars. A total of 15 μL of 0.5 McFarland standard E. faecalis (ATCC 29212) was inoculated into each canal and incubated at 36.5°C for 24 h. The specimens were divided into three groups: Group I (n = 30), control group without intracanal medicament, Group II (n = 30) with Ca(OH)2 and Group III (n = 30) with omeprazole and Ca(OH)2. The numbers of colony forming units (CFUs) were counted after 24 h. The same procedure was repeated after 7 and 14 days for the remaining samples. Statistical analysis was performed using the analysis of variance (ANOVA) test (P < 0.05). We found a significant reduction in the colony-forming unit count in the omeprazole- Ca(OH)2 group. In the Ca(OH)2 group, the number of CFUs was significantly higher than in the omeprazole-Ca(OH)2 group. Omeprazole mixed with Ca(OH)2 was more effective than Ca(OH)2 alone in eliminating E. faecalis.