A Case of Gallbladder Cancer with Ovarian Metastasis in the Third Year after Surgery

A woman in her 60s was diagnosed with gallbladder cancer and pancreaticobiliary maljunction. Extended cholecystectomy and extrahepatic bile duct resection were performed. Macroscopically, the gallbladder cancer was identified as nodular infiltrating in type. The pathological diagnosis was well-differentiated tubular adenocarcinoma, including partially poorly differentiated adenocarcinoma, pT3aN1M0, Stage ⅢB. CT revealed multiple lung metastases 5 months after surgery, but a complete response was achieved with S-1 therapy. CT performed 2 years and 9 months after surgery revealed a left ovarian tumor. Primary or metastatic ovarian cancer was diagnosed. It was found to be histopathologically similar to the poorly differentiated adenocarcinoma component of gallbladder cancer, and ovarian metastasis of gallbladder cancer was diagnosed, together with immunohistochemical findings. Although the ovaries are susceptible to metastases from various primary lesions, ovarian metastases from gallbladder cancer are rare. The prognosis of metastatic ovarian cancer is generally poor. However, aggressive resection should be performed if metastasis is not detected beyond the ovaries.