Role of berberine in metabolic and bone changes in ovariectomized rats.

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Background: This study investigates Berberine's (BBR) impact on metabolic and bone changes in ovariectomized rats, a model for postmenopausal conditions. :

Methods: Sixty adult female rats divided into six groups: control, sham ovariectomized, ovariectomized, and three BBR treated ovariectomized groups (50, 100, and 200 mg/kg/day, for eight weeks). Measurements included serum oestradiol, glucose, HOMA-IR, lipid profile , tumour necrosis factor alpha (TNF-α), oxidative stress markers , osteocalcin (OC), bone-specific alkaline phosphatase (ALP), cross-linked Carboxy-terminal telopeptide of type I collagen (CTX-I), and bone tissue analysis. :

Results: Ovariectomized rats exhibited significant metabolic and bone deterioration, such as increased glucose, insulin, HOMA IR, total cholestrol (TC), LDL-C, TNF-α, OC, ALP, CTX-I, and MDA levels, alongside decreased oestradiol, HDL-C, and GSH levels, and DNA fragmentation (P < 0.001). BBR treatment showed dose-dependent improvements in all parameters. :

Conclusion: BBR demonstrates significant ameliorative effects on metabolic and bone health in ovariectomized rats, highlighting its potential therapeutic benefits for postmenopausal conditions.