Improvement of Hailey-Hailey Disease Following Administration of Dupilumab.

Hailey-Hailey disease (HHD) is a rare, chronic skin disorder characterized by recurrent inflammatory plaques with painful blisters, erosions, and macerations. We report a case of a 40-year-old female with clinical and pathological findings consistent with HHD. After numerous unsuccessful treatments, including the use of antiseptic washes, topical and oral medications, and injections, the patient was started on dupilumab (300 mg/2 mL syringes every 2 weeks). After 4 months of treatment, there was a clearance of plaques and resolution of pain with only minimal residual erythema. This response was maintained with no reported side effects. Dupilumab may be an effective and safe treatment option for refractory HHD, but it necessitates further research. J Drugs Dermatol. 2025;24(4):410-412. doi:10.36849/JDD.8060.