Palladium-Catalyzed Domino Heck/Decarboxylative Cyanomethylation of Indoles and Alkenes with Cyanoacetate Salts.
Journal: Organic Letters
Published:
Abstract
A palladium-catalyzed reaction of indoles with cyanoacetate salts enables the synthesis of 2,6-disubstituted indolines via tandem dearomatization/decarboxylative cyanomethylation. Remarkably, this is the first example of indole difunctionalization at the C2 and C6 positions. Moreover, this methodology extends to the palladium-catalyzed cyclization/decarboxylative cyanomethylation of aryl halide-tethered alkenes.
Authors
Ping-xin Zhou, Yang Liu, Mengjuan Li, Hang Chen, Tao Wu, Xinyang Chen, Kaikai Wang, Feng Ren, Yun Fu, Yong-min Liang