The emerging roles and mechanisms of FAM83H‑AS1 in cancer: Pathophysiology and therapeutic implications (Review).

Long non-coding RNAs (lncRNAs) are key regulators of gene expression at transcriptional and post-transcriptional levels and serve roles in tumour progression, cancer diagnosis and prognosis. Among these, family with sequence similarity 83 member H-antisense RNA 1 (FAM83H-AS1) is an oncogenic lncRNA with elevated expression in several malignancies. FAM83H-AS1 promotes cancer cell proliferation, inhibits apoptosis, enhances migration and contributes to chemoresistance through interactions with microRNA (miR)-136-5p, miR-545-3p, miR-15a miR-10a-5p and signalling pathways such as Wnt/β-catenin and Notch receptor. FAM83H-AS1 may be a promising biomarker for cancer diagnosis and prognosis. The present review summarises the expression, mechanism and potential clinical application of FAM83H-AS1 in cancer diagnosis and prognosis.