Comparison of the Humphrey Field Analyzer and MP-3 Microperimeter in Patients With Glaucoma, Classified by Severity and Misalignment of Test Points.

To compare Nidek MP-3 microperimetry and ZEISS Humphrey Field Analyzer (HFA) visual field (VF) results in patients with primary open-angle glaucoma (POAG), classified by VF defect severity and to describe a novel method for simulating sensitivity distribution changes assumed to be due to fixation errors. This retrospective study used the MP-3 and HFA 10-2 tests to examine the VF in eyes with mild, moderate, or severe POAG, using 68 identical test points. Reliability indices and measurement durations were compared. The relationship between pointwise sensitivities of the devices was analyzed. Thirty-five eyes from 23 patients (10 mild, 12 moderate, and 13 severe POAG) were evaluated. In the severe POAG group, the MP-3 had a significantly lower false-positive (FP) rate and higher false-negative rate than those of the HFA 10-2 (all, P = 0.03). A significant negative correlation existed between the root mean square error, derived from regression analysis comparing the VF sensitivity between devices at each test point, and VF sensitivity of the MP-3 (P < 0.01). In 18 eyes, a shift in the sensitivity distribution occurred, with a significant correlation between the HFA 10-2 mean deviation and the presence of this shift (P < 0.01). Reliability indices differed significantly between the two devices in severe POAG cases. A shift in the sensitivity of the test points of the two VF tests was detected in approximately one-half of the eyes. The MP-3 provides lower FP rates in advanced POAG and may assist in the management of this patient cohort.