Beyond Beauty: Neurocosmetics, the Skin-Brain Axis, and the Future of Emotionally Intelligent Skincare.

The bidirectional communication between the skin and brain has emerged as a promising scientific paradigm in dermatology and cosmetic medicine. Neurocosmetics, a frontier at the intersection of neuroscience, dermatology, and psychodermatology, aim to target this skin-brain axis to enhance not only skin health but also emotional well-being. This commentary explores the underlying neurocutaneous and neuroimmune mechanisms, the emerging role of the skin microbiome in emotion-linked skin responses, and how artificial intelligence (AI) technologies can help personalize these strategies. The convergence of neuroscience and dermatology may pave the way for a new generation of evidence-based skincare with psychophysiological impact, a transformative concept in both clinical and cosmetic practice.