Neutralizing Antibody Responses After mRNA COVID-19 Booster Vaccination are Unaffected by Parasitemia in a Malaria-Endemic Setting.
Journal: MedRxiv : The Preprint Server For Health Sciences
Published:
Abstract
Subclinical malaria may reduce the immunogenicity of mRNA vaccines. We evaluated neutralizing antibody responses in adults with (n=87) and without (n=221) PCR-confirmed Plasmodium falciparum who received a COVID-19 booster. Similar boosted ID50 geometric mean titers >22,000 in parasitemic and non-parasitemic participants suggests that COVID-19 mRNA vaccine responses are not impaired.
Authors
Taraz Samandari, Millicent Achola, Jack Hutter, Grace Mboya, Walter Otieno, Jia Kee, Yunda Huang, John Aponte, Christian Ockenhouse, Cynthia Lee, Laura Polakowski, Margaret Yacovone, Asa Tapley, Sufia Dadabhai, Nonhlanhla Mkhize, Haajira Kaldine, Sinethemba Bhebhe, Penny Moore, John Hural, Nigel Garrett, James Kublin