Changes in clinic-level STI burden after doxycycline post-exposure prophylaxis implementation in an urban sexual health clinic.

In an urban sexual health clinic, a substantial portion of the clinic population initiated doxycycline post-exposure prophylaxis (doxyPEP) for bacterial STIs in the first 12 months, and implementation of doxyPEP was associated with a subsequent decrease in clinic-level chlamydia and syphilis positivity, but no change in overall gonorrhea positivity.