Comparison of first trimester preeclampsia combined screening performances with various approaches in the Indonesian population.

Background: This study aimed to compare Fetal Medicine Foundation (FMF), Indonesian Maternal and Children Health Handbook (MCH-HB), and Indonesian Prenatal Institute (IPI) models for predicting PE.

Methods: Maternal risk factors, biophysical, and biochemical markers were recorded from women screened for PE at 11-14 gestational weeks. The receiving operator curve (ROC) analysis was used to compare the detection rate (DR) among prediction models.

Results: For all PE at a 10% false-positive rate (FPR), FMF had a DR 62.9%; MCH-HB had a DR 50.0%; IPI had a DR 66.9%. For early-onset PE, at 10% FPR FMF had a DR 80.3%; MCH-HB had a DR 71.4%; IPI had a DR 81.5%. For preterm PE at 10% FPR, FMF had a DR 70.2%; MCH-HB had a DR 38.5%; IPI had a DR 66.9%.

Conclusions: IPI algorithm is comparable to FMF and outperforms MCH-HB algorithm for all, early-onset, and preterm PE screening.