Regional Therapies for Melanoma and Merkel Cell Carcinoma.

Melanoma and Merkel cell carcinoma (MCC) have the potential to develop into advanced, regionally metastatic disease that is not always amenable to resection and is associated with a worse survival. Intralesional therapies, including oncolytic vaccines, xanthene dyes, immune modulating cytokines, and regional perfusions such as isolated limb infusion and perfusion, including isolated limb and hepatic perfusion and percutaneous hepatic perfusion, have been used in the treatment of advanced cutaneous and uveal melanoma and MCC. These therapies are effective and have a role in the multimodality treatment of these patients and may be synergistically used with conventional immune and targeted therapies.