The Comorbidities of Hidradenitis Suppurativa.

Hidradenitis suppurativa (HS) is a chronic inflammatory disease that drammatically decreases the quality of life for afflicted patients. A number of factors may co-exist with HS: stigmatization, social isolation, tobacco use, alcohol abuse, suicidal ideation, depression, other psychiatric disorders, plus medical comorbidities that include obesity, diabetes mellitus, hypertension, dyslipidemia, metabolic syndrome, coronary artery disease, and polycystic ovarian syndrome may coexist with hidradenitis suppurativa. These comorbidities should be kept in mind while planning the treatment. A rare but important long-term complication of hidradenitis suppurativa is squamous cell cancer; men with perianal, gluteal, or perineal lesions are at increased risk, and multiple biopsies should be taken in case of any suspicious lesions.