Correlation of mean platelet volume and red blood cell distribution width with obstructive sleep apnoea syndrome severity.

Background: Mean platelet volume (MPV) and red blood cll distribution width (RDW) have been assosiated with sleep apnea syndrome severity.

Objective: To investigate the correlation of mean platelet volume and red blood cell distribution width with obesity sleep apnoea syndrome (OSAS) severity.

Methods: Ninety patients underwent PSG. Patients with an apnoea-hypopnoea index (AHI) <5 were used as controls. Patients with AHI >5 were divided into mild: 5 ≤ AHI <15, moderate: 15≤ AHI <30 and severe OSAS: AHI ≥30. Patients >65 years, with body mass index (BMI) >40, central sleep apnoea syndrome, cardiovascular or other significant comorbidities were excluded. Blood sample collection occurred one day before polysomnography (PSG).

Results: Sixty-four patients were included in our study. Fifty-seven (89.1%) had OSAS (16% mild, 25% moderate and 48.4% severe) while the remaining 7 (10.1%) were used as controls. MPV was similar among groups [8.1 (7.1, 9.2) vs 7.9 (6.8, 10.1) vs 8.5 (7.4, 9.1) vs 8.4 (7.6, 9.7), P = .930 for control, mild, moderate and severe OSAS, respectively]. RDW did not differ between OSAS patients and control [median (IQR) 14.4 (13.4, 15.3) vs 14.0 (13.5, 16.7), P = .950], while there was no significant difference among different stages of OSAS severity [14.0 (13.5, 16.7) vs 13.9 (11.4, 14.8) vs 14.4 (14.0, 15.3) vs 14.4 (13.3, 15.6), P = .517] for control, mild, moderate and severe OSAS, respectively.

Conclusions: OSAS patients have elevated levels of RDW and MPV compared to controls; however, there was no association between OSAS severity and MPV or RDW.