Combination chemotherapy of transplanted rat leukemia L 5222 with 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) and cyclophosphamide (CPA) as well as with methyl-CCNU and CPA (author's transl)

The acute transplanted rat leukemia L 5222 was used to investigate the two-drug combinations 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) and cyclophosphamide (CPA) as well as methyl-CCNU and CPA. A therapeutic synergism could not be demonstrated in either combination. In both combinations the monotherapy with the nitrosourea was superior to the combination as well as to the monotherapy with CPA.