Anemias due to erythroblastopenia

Anaemias caused by pure red cell aplasia may regress spontaneously (acute) or remain chronic. They have multiple causes, the most frequent of which, in chronic pure red cell aplasia, is chronic lymphocytic leukaemia. It is important to find that the anaemia is due to pure red cell aplasia since this may raise hopes of cure after an immunosuppressive treatment. In patients with chronic pure red cell aplasia the in vitro study of erythroid precursors has a prognostic value.