Two cases of primary open angle glaucoma with serum autoantibody against retinal ganglion cells.

Objective: To present two cases of primary open angle glaucoma (POAG) with serum autoantibody against retinal 25 kDa or 50 kDa antigen.

Methods: Ocular examinations were performed on a 60-year-old man (case 1) and a 74-year-old woman (case 2). We also performed serological and immunological examinations including Western blot analysis and immunocytochemical analysis.

Results: In Western blot analysis, they were found to have serum autoantibody against retinal 25 kDa or 50 kDa antigen, and immunocytochemical analysis revealed that retinal ganglion cell layers were specifically labeled by each patient's IgG.

Conclusions: We report two interesting cases of POAG with serum autoantibody against retinal 25 kDa or 50 kDa antigen.