Posterior capsule opacification and neodymium: YAG capsulotomy with heparin-surface-modified intraocular lenses.

Objective: To compare the effect of heparin-surface-modified (HSM) and conventional unmodified poly(methyl methacrylate) (PMMA) intraocular lenses (IOLs) on the formation of posterior capsule opacification (PCO).

Methods: Department of Ophthalmology, Vejle Hospital, Denmark. Methods: This prospective, randomized, double-blind study comprised 250 eyes of 246 patients who had uneventful extracapsular cataract extraction in otherwise healthy eyes with implantation of a biconvex IOL or a convex-plano lens with a continuous laser ridge. Patients were examined once a year for 3 years, at which time the degree of PCO was recorded. A neodymium:YAG laser capsulotomy was performed if certain criteria were met.

Results: The incidence of PCO was statistically significantly higher in eyes with an HSM convex-plano laser-ridge IOL than in those with an unmodified convex-plano lens (P < .005). There were no significant differences between any other groups.

Conclusions: The incidence of PCO was higher in eyes with an HSM convex-plano IOL with a laser ridge.