Acute anterior uveitis, systemic diseases and HLA-B27

The author investigated the rate of phenotype HLA-B27 and systemic diseases in patients with acute anterior uveitis (AAU) in our geographical area. The evaluated clinical differences of AAU manifestations in HLA-B27 positive and HLA-B27 negative patients in a group of 104 subjects followed up for a 10-year period. The patients were under 40 years of age. Men were affected twice as frequently as women. HLA B27 positive AAU is manifested above all by serofibrous exsudation into the anterior chamber and by more frequent relapses. In patients with early treatment there were fewer complications and the prognosis was favourable. AAU in HLA-B27 positive patients is associated in 65% with rheumatic disease. In our population it is above all ankylosing spondylitis and Reiter's disease. In 71% rheumatic diseases were manifested in men. Despite the different clinical course of AAU HLA-B27 positive and negative patients, during long-term follow up the visual acuity is not markedly altered in any of the investigated groups.