Functional loading tests in nephropathy examination in patients recovering from hemorrhagic fever with renal syndrome

Objective: To characterize nephropathy in patients recovering after hemorrhagic fever with renal syndrome (HFRS) using functional loading tests.

Methods: In 65 HFRS convalescents we examined renal function under water deprivation, exercises and studied intraglomerular hemodynamics.

Results: After 2-month follow-up renal functional reserve was absent in 34% of the convalescents indicating intraglomerular hypertension. Under water deprivation most of the patients showed persistent tubulointerstitial disorders. Submaximal muscular exercises aggravated glomerular and tubular dysfunction manifesting with microalbuminuria, increased excretory beta 2-microglobulin fraction, low concentration reserve.

Conclusions: Functional loading tests provide more detailed characterization of renal function in HFRS convalescents.