Urinary endothelin-1 in children with glomerulonephritis.

Urinary endothelin-1 (ET-1) excretion was studied in 28 children with glomerulonephritis. Urinary ET-1 excretion was expressed as a ratio of urinary ET-1 to urinary creatinine (ET-1/Cr). There was a positive correlation between urinary ET-1/Cr and daily total urinary ET-1 in patients (r = 0.65, n = 32, p < 0.001). Urinary ET-1/Cr in children with glomerulonephritis and normal renal function was not different from that of normal controls. Urinary ET-1/Cr in glomerulonephritis children with ARF was lowest. These results showed that the pattern of urinary ET-1/Cr varied depending on the state of renal function in children with glomerulonephritis.