Klinefelter's syndrome and precocious puberty: a harbinger for tumor.
Journal: Urology
Published:
Abstract
Boys with Klinefelter's syndrome are at an increased risk of precocious puberty. Most cases are either idiopathic or due to a mediastinal tumor. Patients with Klinefelter's syndrome are at a high risk of primary, extragonadal germ cell tumors, which are usually nonseminomatous, but can be a mixed type with seminomatous elements. The differential diagnosis of precocious puberty includes mediastinal tumors, especially in boys with Klinefelter's syndrome.
Authors
Eric Kurzrock, Hari Siva Gurunadha Tunuguntla, Joseph Busby, Regina Gandour Edwards, Laurence Goldman
Relevant Conditions