Impact of prior nicotine replacement therapy on smoking cessation efficacy.
Journal: American Journal Of Health Behavior
Published:
Abstract
Objective: To examine previous use of nicotine replacement therapy (NRT) on the smoking-cessation efficacy of bupropion sustained release (SR).
Methods: Secondary analysis of a parallel-group, randomized, double-blind, placebo-controlled study. Smokers who had, based on self-report, no previous history of NRT (N = 453) or who had used NRT at least once (N = 440) were randomized to receive placebo, bupropion SR, nicotine transdermal system (NTS), or a combination of bupropion SR and NTS.
Results: Bupropion SR showed similar efficacy in participants with or without previous use of NRT.
Conclusions: Bupropion SR is effective in promoting smoking abstinence regardless of prior NRT use.
Authors
Michael Durcan, Jonathan White, Douglas Jorenby, Michael Fiore, Stephen Rennard, Scott Leischow, Mitchell Nides, John Ascher, J Johnston