Tandem hydroformylation/Fischer indole synthesis: a novel and convenient approach to indoles from olefins.
Journal: Organic Letters
Published:
Abstract
[reaction: see text] A novel one-pot synthesis of indole systems via tandem hydroformylation/Fischer indole synthesis starting from olefins and arylhydrazines is described. This tandem procedure leads directly to 3-substituted indoles if unsubstituted phenylhydrazine is used and to 3,5- respectively 3,7-disubstituted indoles if para- or ortho-substituted arylhydrazines are used.
Authors
Petra Köhling, Axel Schmidt, Peter Eilbracht