Premature ovarian failure and fragile X premutation: a study on 45 women.
Journal: European Journal Of Obstetrics, Gynecology, And Reproductive Biology
Published:
Abstract
Objective: The aim of this study was to test for the presence of the fragile X (FRAXA) premutation a group of women with early menopause.
Methods: 45 women with idiopathic premature ovarian failure (POF), five with a familial and 40 with a sporadic form, were screened for the presence of FRAXA premutation. A control group of 28 women >45 years, with one or more children and no signs of POF, was also studied.
Results: We found three cases of fragile X premutations in women all belonging to the group with sporadic POF.
Conclusions: Our results seems to confirm previous observations on the non random association between POF and FRAXA premutation.
Authors
Cecilia Bussani, Laura Papi, Roberta Sestini, Fulvia Baldinotti, Sandra Bucciantini, Vincenzina Bruni, Gianfranco Scarselli
Relevant Conditions