Nicorandil associated anal ulceration.

Objective: Nicorandil is a vasodilator used to control angina. It has been associated with oral and anal ulceration that resolves upon withdrawal of the drug.

Methods: We report a series of 13 patients with nonspecific anal ulceration all of whom were receiving nicorandil for control of symptoms of ischaemic heart disease.

Results: All the ulcers had similar clinical and histological appearances. All the ulcers healed on withdrawal of the drug.

Conclusions: Nicorandil-associated anal ulceration should be considered in the differential diagnoses of nonhealing anal ulcers.