Regulation of phosphate balance in the kidney

The reabsorption of phosphate filtered at glomeruli is mediated by sodium-dependent phosphate (Na/Pi) cotransporter families in the brush border membrane of the proximal tubuli. The type II a Na/Pi cotransporter plays the most important role for renal phosphate reabsorption and is regulated by several factors, e.g. parathyroid hormone (PTH) and fibroblastic growth factor-23. PTH induces endocytosis of the type II a Na/Pi cotransporter from the brush border membrane and subsequent lysosomal degradation, and the decrement of the type II a Na/Pi cotransporter in the brush border membrane leads the phosphate reabsorption inhibition.